Assessment of Changes in Functional Brain Connectivity During Depression Treatment with TMS Using Granger Causality Based Methods

Directed transfer function (DTF) method was used to assess brain connectivity disturbances in depression. The results were depicted as a model with the electroencephalographic (EEG) registration points, through which directions of bioelectric activity are defined. Transcranial magnetic stimulation (TMS) is an alternative treatment for drug-resistant depression and considered restore impaired connections. combination TMS EEG allows study changes functional (FBC) non-invasive way. It found that FBC resistant patients differed more from healthy subjects than non-resistant patients. largest identified theta frequency.